The crash was reported at just after 3 p.m. along Middle River Road at Martin Boulevard.
Initial reports indicate that a Parkville High School bus collided with a police cruiser.
Seven occupants of the bus are being evaluated.
Several other vehicles were also involved in the crash.
The officer in the police cruiser was reportedly injured and taken to a hospital with minot injuries.
The police cruiser was on route to a second crash along Martin Boulevard at Windlass Drive near Martin Plaza in which both vehicles were on fire.
Martin Boulevard has been shut down.
Motorists should avoid the area.