The crash was reported at about 3 p.m. along north/east-bound Pulaski Highway between White Marsh Boulevard and Ebenezer Road.
Units from the White Marsh, Middle River, and Chase fire companies are responding to the scene.
A total of six vehicles were involved in the crash and four people were injured.
There was also a crash along northbound I-95 and a medical emergency along southbound I-95 on Friday afternoon.
Motorists should expect delays in the area.